Electric Literature of 60702-69-4, The chemical industry reduces the impact on the environment during synthesis 60702-69-4, name is 2-Chloro-4-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.
Phenol (3.66 g, 39 mmol) dissolved in DMF (30 mL),It was treated with NaH 60% (1.56 g, 39 mmol) dispersed in oil in small portions until gas evolution ceased. The reaction mixture was stirred at room temperature for 10 minutes,Then 2-chloro-4-fluorobenzonitrile (2-A, 5.0 g, 32.5 mmol) was added. The mixtureStir for 3 hours at room temperature until completion (LCMS).Volatiles were removed in vacuo and the crude product was partitioned between DCM / water.The organic phase is separated, washed with saturated aqueous salt solution,Dried over Na2SO4.Concentration gave 7.5 g of an off-white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Arqule, Inc; Lapierre, Jean-Marc; Eathiraj, Sudharshan; Namdev, Nivedita; Momose Takayuki, Brian; Ota, Yusuke; Momose, Takayuki; Tsunemi, Tomoyuki; Inagaki, Hiroaki; Nakayama, Kiyoshi; (35 pag.)JP2020/59741; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts