2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 2042-37-7
General procedure: Phenylboronic acid (1.5mmol), aryl chloride (1.0mmol), K2CO3 (2.0mmol), PEPPSI-type palladium-NHC catalyst (0.01mmol, 1mol%) (2a-f) and mixture of isopropanol/water (1:3; v/v) (4mL) were added to a small round bottom flask in air. The mixture was stirred at 50C for 2h. At the end of the reaction, the cooled solution to room temperature was extracted with a mixture of EtOAc/n-hexane (1:5, v/v). The organic phase was separated and dried over anhydrous MgSO4, the solution passed through the micro silica gel column was concentrated. Product characterizations were performed by GC. The reaction yields were determined by GC based on aryl chloride.
The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kalo?lu, Nazan; Oezdemir, ?smail; Tetrahedron; vol. 75; 15; (2019); p. 2306 – 2313;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts