Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-84-7, name is 3-Chlorobenzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 3-Chlorobenzonitrile
EXAMPLE 13; 5-(1-chloroethyl)-3-(3-chlorophenyl)-1,2,4-oxadiazole; (i) 3-chloro-N’-hydroxybenzenecarboximidamide; Sodium hydroxide (8.2 g in 50 mL water) and hydroxylamine hydrochloride (16 g in 20 mL water) were added to a solution of 3-chloro-benzonitrile (28 g, 203.5 mmol) at 80 C. in ethanol (50 mL). The resulting mixture was stirred for 2 h. at 80 C. The solvent was removed in vacuo. to afford the title compound (29.82 g, 85.9%). 1H NMR (300 MHz, CDCl3): delta (ppm) 7.65 (s, 1H), 7.52 (d, 1H), 7.41 (d, 1H), 7.35 (t, 1H), 4.86 (br, 2H), 1.68 (br, 1H).
The synthetic route of 766-84-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AstraZeneca AB; NPS PHARMACEUTICALS, INC.; US2007/37820; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts