Related Products of 2973-50-4,Some common heterocyclic compound, 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(2-Aminophenyl)acetonitrile (9) (2.64 g, 20.0 mmol) was dissolved in 50 mL of acetic acid. KI (3.65 g, 22.0 mmol) was added followed by dropwise addition of 30% H2O2 (2.24 mL, 22.0 mmol). The reaction mixture was then stirred under nitrogen for 90 min, poured into 200 mL of 0.1 M sodium thiosulfate solution, and extracted with ethyl acetate (3 ¡Á 200 mL). The organic fractions were combined, washed with 0.1 M sodium thiosulfate (2 ¡Á 200 mL), satd sodium bicarbonate (2 ¡Á 200 mL) and brine (2 ¡Á 200 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Purification by automated flash chromatography (400 g silica gel, 25% ethyl acetate/hexanes) afforded 10 (3.5 g, 68%). 1H NMR (400 MHz, DMSO-d6) delta ppm: 5.41 (s, 2H), 6.53 (d, J = 8.34 Hz, 1H), 7.30 (dd, J = 8.59, 2.02 Hz, 1H), 7.39 (d, J = 2.02 Hz, 1H), NH2 protons not resolved.
The synthetic route of 2973-50-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bobko, Mark A.; Evans, Karen A.; Kaura, Arun C.; Shuster, Leanna E.; Su, Dai-Shi; Tetrahedron Letters; vol. 53; 2; (2012); p. 200 – 202;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts