Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39581-21-0, name is N-Butyl-2-cyano-acetamide, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks
General procedure: A mixture of a salicylaldehyde (1a or 1b, 1 mmol), N-alkyl-2-cyanoacetamides (2a-2f,1 mmol), and {Mo132} (0.05 g) was heated in an oil bath at 110 C for 5-15 min. Aftercompletion of the reaction, monitored by TLC on silica gel (n-hexane-ethyl acetate,3:2), the mixture was cooled to room temperature and hot ethanol (10 ml) was added.The catalyst was collected by filtration and washed with a small portion of hot ethanol(5 ml). The combined filtrate was concentrated by half and allowed to stand at roomtemperature. The precipitated solid was collected by filtration, and recrystallized from96% ethanol to give compounds 3a-3i in high yields (see Table 2).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Jooya, Arsalan; Davoodnia, Abolghasem; Fattahi, Mehri; Tavakoli-Hoseini, Niloofar; Organic Preparations and Procedures International; vol. 50; 6; (2018); p. 565 – 574;,
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