147754-12-9, name is 4-Fluoro-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Fluoro-2-methylbenzonitrile
In a dried reaction flask, 4-fluoro-2-methylbenzonitrile (4.055g, 30.0mmol) and hydrazine hydrate (85percent) (3.54mL, 60.0mmol) were dissolved in ethanol (15.9mL). In the protection from light and under the nitrogen atmosphere, the solution was heated under reflux at 80¡ãC for 48hr. Water was added to the reaction solution. The mixture was filtered. The filtered cake was rinsed with water to produce a pale yellow solid, which was suspended in ethyl ether. A hydrogen chloride gas was passed into the suspension under an ice-salt bath. The suspension was filtered. The filtered cake was rinsed with ethyl ether to produce an off-white solid (2.04g) in 37.0percent yield.
The synthetic route of 147754-12-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KBP Biosciences Co., Ltd.; HUANG, Zhenhua; WANG, Jinyuan; ZHANG, Dedong; EP2607363; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts