These common heterocyclic compound, 147754-12-9, name is 4-Fluoro-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Fluoro-2-methylbenzonitrile
2-methyl-4-fluorophenyl-carbonitrile (2g, 14.8mM, 1.0equiv) in carbon tetrachloride (24mL) was added N- bromosuccinimide (2.64g, 14.8mM, 1.0equiv ), benzoyl peroxide (BPO, 179mg, 0.74mM, 0.05equiv), and heated to reflux for 3h under nitrogen. The reaction was complete by TLC, cooled to room temperature, filtered, washed with carbon tetrachloride, the solvent was concentrated under reduced pressure to give the crude product as a white solid. It was used directly in the next reaction without purification.
The synthetic route of 4-Fluoro-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chengdu Bestchiralbio Limited-Liability Company; Li, Dequn; (16 pag.)CN105272963; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts