Synthetic Route of 105-34-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 105-34-0 as follows.
The mixture of benzaldehyde (0.5 mmol) and methyl cyanoacetate(0.5 mmol) in toluene 1 mL was incubated in the presence of Candida cylindracea lipase (30 mg) at 50 C for 4 days. The reaction was monitored by TLC analysis. After this time enzyme was filtered out and the solvent was evaporated in vacuo. The resulting residue was purified by column chromatography (silica gel, eluent ethyl acetate/hexanes) to obtain desired product 5a with 40% yield. 4.7. Characterization of obtained products 5a-u.4.7.1. Methyl (E)-2-cyano-3-phenylprop-2-enoate; (5a)White solid; melting point 89 C; 1H NMR (400 MHz, CDCl3) delta 8.20(s, 1H), 7.92 (dd, J=7.1, 1.5 Hz, 2H), 7.53-7.40 (m, 3H), 3.87 (s, 3H).13C NMR (100 MHz, CDCl3) delta 162.9, 155.3, 133.4, 131.4, 131.1, 129.3,115.4, 102.6, 53.4. All the resonances of 1H, 13C NMR spectra andmelting point were consistent with reported values [32]
According to the analysis of related databases, 105-34-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wilk, Monika; Trzepizur, Damian; Koszelewski, Dominik; Brodzka, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
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