Adding a certain compound to certain chemical reactions, such as: 1558-81-2, name is Ethyl 1-Cyano-1-cyclopropanecarboxylate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1558-81-2, Formula: C7H9NO2
To a solution of ethyl 1 -cyanocyclopropanecarboxylate (1-127) (5 g, 36 mmol) in DME/MeOH (80 mL/8 mL) was added NaBH4 (10.65 g, 0.288 mol) in a portionwise manner at 0 ~ 5 C. The mixture was stirred at room temperature for 4 hr. TLC (petroleum ether: EtOAc=1 :1 ) showed the reaction was complete. The reaction mixture was diluted with saturated aq. NaHC03 (60 mL) and then extracted with 10% MeOH/CH2CI2 (8 x 100 mL). The combined organic layers were dried over Na2S04 and concentrated to give 1 -(hydroxymethyl)cyclopropanecarbonitrile (1-128) (3 g, 85%) as a light yellow oil, which was used without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-Cyano-1-cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts