Synthetic Route of 10406-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10406-25-4 name is 4-(Aminomethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture of TBPB (1 mmol) and requisite aq NH3 or amine (1.1mmol) were charged in a round-bottom flask. The reaction mixture was stirred at r.t. for the indicated time, and progress of the reaction was monitored by TLC/GC. The crude product was directly purified by column chromatography (silica gel, 100-200 mesh, PE-EtOAc) to provide the desired pure product. The identity of the compound was confirmed by 1H NMR and 13C NMR spectroscopic methods.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Aminomethyl)benzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Yadav, Dilip Kumar T.; Bhanage, Bhalchandra M.; Synlett; vol. 26; 13; (2015); p. 1862 – 1866;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts