Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks
0.60g (0.015 mol) of sodium hydroxide was added to a solution of 1.22g(0.0075 mol) of 3,5-dichloropyridin-4-amine in 40 mL of DMF, followed by addition of 2g (0.0075 mol) of 3,4,5,6-tetrachlorophthalonitrile under stirring, themixture was stirred for 5 h after addition at room temperature. After the reaction was over by Thin-Layer Chromatographymonitoring, the reaction mixture was poured into water and extracted with ethyl acetate, the organic phase was washedwith water and saturated brine, dried over anhydrous magnesium sulfate, filtered and then concentrated under reducedpressure. The residue was purified through silica column (ethyl acetate/petroleum ether (boiling point range 60-90¡ãC)= 1:4, as an eluent) to give 2.6 g of compound A-87 as yellow solid, m.p. 214-216¡ãC.[0070] 1H-NMR (300MHz, internal standard TMS, solvent DMSO), 8.26(s, 2H, Py-2,6-2H), 11.0(br, 1H, NH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1953-99-7, its application will become more common.
Reference:
Patent; Sinochem Corporation; Shenyang Research Institute of Chemical Industry Co., Ltd.; LIU, Changling; HUANG, Guang; LAN, Jie; HAO, Shulin; LI, Zhinian; LI, Huichao; GUAN, Aiying; JIANG, Airu; XU, Ying; EP2757092; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts