Synthetic Route of 53312-82-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53312-82-6, name is 4-Amino-2-bromobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-amino-2-bromobenzonitrile (0.055 g, 0.281 mmol) was stirred in dichloromethane (2 mL) and 0.50 mL saturated sodium bicarbonate solution (0.024 g, 0.281 mmol) solution at 0 C. Phosgene (20% in toluene, 0.3 mL, 0.561 mmol) was added and stirred for 30 min. The organic layer was extracted with dichloromethane and washed with water followed by sodium bicarbonate solution. The organic layer was concentrated and redissolved in DMF (2 mL). 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine (0.050 g, 0.281 mmol) was added and heated at 90 C for 1 h. The resulting solid was filtered and washed with water, ethyl acetate and acetone to yield compound 24 as a pure solid (0.045 g, 0.112 mmol, 40%). See below for characterization data.
The synthetic route of 4-Amino-2-bromobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Rosenthal, Andrew S.; Dexheimer, Thomas S.; Gileadi, Opher; Nguyen, Giang H.; Chu, Wai Kit; Hickson, Ian D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 20; (2013); p. 5660 – 5666;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts