Reference of 4110-35-4,Some common heterocyclic compound, 4110-35-4, name is 3,5-Dinitrobenzonitrile, molecular formula is C7H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of nitrile (1 mmol), sodium azide (1.5 mmol), Cu complex catalyst (0.4 mol%) and DMF (3 mL) was taken in a round-bottomed flask and stirred at 110 C temperature. After completion of the reaction the catalyst was separated from the reaction mixture with an external magnet and reaction mixture was treated with ethyl acetate (2 ¡Á 20 mL) and 1 N HCl (20 mL). The resultant organic layer was separated and the aqueous layer was again extracted with ethyl acetate (2 ¡Á 15 mL). The combined organic layers were washed with water, concentrated, and the crude material was chromatographed on silica gel (Hexane-EtoAc, 1:1) to afford the pure product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dinitrobenzonitrile, its application will become more common.
Reference:
Article; Esmaeilpour, Mohsen; Javidi, Jaber; Nowroozi Dodeji, Fatemeh; Mokhtari Abarghoui, Mehdi; Journal of Molecular Catalysis A: Chemical; vol. 393; (2014); p. 18 – 29;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts