Application of 26830-95-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26830-95-5 as follows.
a 2-Amino-4-methylbenzonitrile A mixture of 4-methyl-2-nitrobenzonitrile (4.9 g, 30 mmol) and 10% palladium on carbon (500 mg) in 1,4-dioxane (60 mL) was stirred under hydrogen (balloon) overnight. The catalyst was removed by filtration through the Celite, and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography (dichloromethane) to give the title compound as a pale yellow solid (3.3 g, 83%). 1 H-NMR (300 MHz, CDCl3) delta 7.26 (d, J=8.3 Hz, 1H), 6.56 (s, 1H), 6.55 (s, 1H), 4.32 (br s, 2H), 2.29 (s, 3H).
According to the analysis of related databases, 26830-95-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; 3-Dimensional Pharmaceuticals, Inc.; US5891909; (1999); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts