In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57381-49-4 as follows. Quality Control of 2-Bromo-4-chlorobenzonitrile
2-bromo-4-chlorobenzonitrile 1 g (1.18 g, 5.48 mmol) and 1f (1.3 g, 5.48 mmol) were added to 20 mL of 1,4-dioxane, followed by[1,1′- (Diphenylphosphino)ferrocene]dichloropalladium (240 mg, 0.33 mmol) and potassium carbonate(2.3 g, 16.4 mmol) were added. The reaction mixture was heated to 100-110C and the reaction was stirred for 16 hours.The reaction solution was allowed to cool to roomtemperature and 50 mL of water was added to the reaction mixture. The mixture was extracted with ethyl acetate (50 mL ¡Á 3). The organic phases were combined and the organic phase was washed with water(50 mL) and saturated sodium chloride solution (50 mL). After drying over anhydrous sodium sulfate, the desiccant was removed by filtration and the filtrate was concentrated under reduced pressure.The resulting residue was purifiedwith aCombiFlash flash reader using eluent system B to give the title product 1h (570 mg, colorless oil), yield: 31.6%.
According to the analysis of related databases, 57381-49-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; Yang Fanglong; Chi Jiangtao; He Feng; Tao Weikang; (33 pag.)CN107793396; (2018); A;,
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