Application of 53312-81-5, These common heterocyclic compound, 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The synthesis was carried out by using the synthetic method c. To a solution of 3-aminobenzonitrile (0.603 g, 3.39 mmol)and DIPEA (1.09 g, 8.46 mmol) in dichloromethane (40 mL) was added picolinoyl chloride HCl salt (0.562 g, 3.39 mmol). The mixture was stirred for 4 h. The mixture solution was injected into a silica-gel column (40 g) andpurified by CombiFlash eluting with dichloromethane and ethyl acetate to give the product as a white solid (630.2 mg, 2.82 mmol, 83.3% yield)
The synthetic route of 53312-81-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Zhaoda; Kil, Kun-Eek; Poutiainen, Pekka; Choi, Ji-Kyung; Kang, Hye-Jin; Huang, Xi-Ping; Roth, Bryan L.; Brownell, Anna-Liisa; Bioorganic and Medicinal Chemistry Letters; vol. 25; 18; (2015); p. 3956 – 3960;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts