Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3441-01-8, name is 3-Cyanobenzamide, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Cyanobenzamide
Under argon, tert-butyl 4-(10-bromo-2-oxo-l,2-dihydropyrimido[l,2-b]indazol-4-yl)piperidine-l- carboxylate (200 mg, 447 muiotaetaomicron), 3-cyanobenzamide (163 mg, 1.12 mmol), Tripotassium phosphate (133 mg, 626 muiotaetaomicron), tBuBrettPhos (13.0 mg, 26.8 muiotaetaomicron), and tBuBrettPhos Pd G3 (22.9 mg, 26.8 muiotaetaomicron) were dissolved in l-Methoxy-2-propanol (5.0 ml, 52 mmol). The mixture was stirred at 110 ¡ãC for 16 h and then purified via reverse phase chromatography (Method: Reprosil C18; 10 muiotaeta; 125×30 mm / flow: 50 ml/min / solvents: A = water (0,01percent formic acid), B = Acetonitrile / gradient 0.00-4.25 min = 20percentB, 4.50min = 30percentB, 19.00-22.50min = 100percentB, 22.75-25.00min = 20percentB) which afforded the product after drying in vacuo. The obtained amout was 130 mg (100 percent purity, 57 percent of theory). LC-MS (Method 1): Rt = 1.15 min; MS (ESIpos): m/z = 513 [M+H]+
The synthetic route of 3441-01-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ELLERMANN, Manuel; VALOT, Gaelle; CANCHO GRANDE, Yolanda; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; BEYER, Kristin; ROeHRIG, Susanne; SPERZEL, Michael; STAMPFUSS, Jan; MEYER, Imke; KOeLLNBERGER, Maria; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; (308 pag.)WO2016/173948; (2016); A1;,
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