Reference of 873-32-5,Some common heterocyclic compound, 873-32-5, name is 2-Chlorobenzonitrile, molecular formula is C7H4ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Typically, an aryl chloride (2.0 mmol), phenylboronic acid (3.0 mmol), Pd(at)NPad2-1.0 catalyst (5.4 mg, 0.02 mol% Pd), K2CO3 (552.8 mg, 4.0 mmol) and 4.0 mL of i-PrOH/water (1:1) were added into a 25 mL pressure tube under Ar. The reaction mixture was stirred at 100 C for 18 h in an oil bath. After the reaction mixture cooled down to room temperature, the product was isolated by column with silica gel and analyzed by 1H NMR.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chlorobenzonitrile, its application will become more common.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts