Synthetic Route of 50397-74-5, The chemical industry reduces the impact on the environment during synthesis 50397-74-5, name is 4-Amino-3-bromobenzonitrile, I believe this compound will play a more active role in future production and life.
Diethyl ethoxymethylenemalonate (8.23 g, 38.1 mmol) was added to a solution of 1 (5.00 g, 25.4 mmol) in 30 mL of toluene. The mixture was then heated to reflux overnight with the condenser open to the air. The resulting solution was cooled down to room temperature and poured into 100 mL of hexanes. The white precipitate was collected and washed with hexanes (3 * 30 mL) to yield 11.9 g of an off-white solid as the desired product. MS ESI (m/z) 367 (M + 1)+; 1H NMR (CDCl3, 300 MHz): delta 11.44 (d, 1H, J = 12.6 Hz), 8.44 (d, 1H, J = 12.9 Hz), 7.86 (d, 1H, J = 1.8 Hz), 7.63 (dd, 1H, J1 = 1.8 Hz, J2 = 8.7 Hz), 7.33 (d, 1H, J = 8.4 Hz), 4.35 (q, 2H, J = 6.9 Hz), 4.27 (q, 2H, J = 6.9 Hz), 1.38 (t, 3H, J = 6.9 Hz), 1.33 (t, 3H, J = 6.9 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-3-bromobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fiorito, Jole; Saeed, Faisal; Zhang, Hong; Staniszewski, Agnieszka; Feng, Yan; Francis, Yitshak I.; Rao, Sudha; Thakkar, Devarshi M.; Deng, Shi-Xian; Landry, Donald W.; Arancio, Ottavio; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 285 – 294;,
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