Electric Literature of 115661-37-5, A common heterocyclic compound, 115661-37-5, name is 2-Amino-3-fluorobenzonitrile, molecular formula is C7H5FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 100 mL of the round bottom flask was added 1 g (about 7.35 mmol) of 2-amino-3-fluorobenzonitrile, 4.88 mL (about 36.73 mmol) of N,N-dimethylformamide dimethyl acetal and 15 mL of solvent methanol. The reaction in the round bottom flask was then stirred under reflux for 6 hours. The solvent and excess reactants are removed by distillation under reduced pressure. Intermediate (E)-N’-(2-cyano-6-fluorophenyl)-N,N-dimethylformamidine 1.4 g is obtained. The yield is 99%,
The synthetic route of 115661-37-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhengzhou University; Liu Hongmin; Yu Bin; Yuan Shuo; Zhang Danqing; (31 pag.)CN110078675; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts