Related Products of 16588-02-6,Some common heterocyclic compound, 16588-02-6, name is 2-Chloro-5-nitrobenzonitrile, molecular formula is C7H3ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a) 5-nitro-2-phenylaminobenzonitrile 2-Chloro-5-nitrobenzonitrile (Aldrich) (3.64grams (hereinafter ‘g’), 20 millimoles (hereinafter ‘mmol’), aniline (2 milliliter (hereinafter ‘mL’), 22 mmol), N-methylpyrollidine (10 mL) and diisopropylethylamine (4 mL) were combined and heated to 120 under Ar for 18 hours (hereinafter ‘h’), cooled, poured into EtOAc (150 mL), washed with H2O (3X 50 mL) and saturated aqueous (hereinafter ‘satd. aq.) NaCl (50 mL), dried (Na2SO4), concentrated, and the residue was triturated with hexane, filtered and the solid was washed with hexane and dried in vacuo to afford 4.23 g (88%) of the title compound as a light green solid. 1H NMR (400) MHz, delta: 8.45 (finely split doublet, 1), 8.19 (dd, 1), 7.48 (m,3), 7.28 (d,2), 7.06 (d,1), 6.96 (br s,1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-5-nitrobenzonitrile, its application will become more common.
Reference:
Patent; SmithKline Beecham Corporation; EP1233951; (2005); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts