A new synthetic route of 332-25-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethoxy)benzonitrile, its application will become more common.

Synthetic Route of 332-25-2,Some common heterocyclic compound, 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, molecular formula is C8H4F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the same manner as in Reference Example 1, the title compound was obtained. Melting point: 222-225¡ã C. NMR (CDCl3( delta: 5.19(2H,s), 5.92(2H,s), 7.25-7.45(5H,m), 7.73(1H,d,J=8.8 Hz), 8.46 (1H,s). Elemental analysis for C20H11F3O5 Calcd: C, 61.86percent; H, 2.86percent Found: C, 64.79percent; H, 2.79percent

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethoxy)benzonitrile, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6340704; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts