Adding a certain compound to certain chemical reactions, such as: 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 194853-86-6, Computed Properties of C8H3F4N
Reference Example 44 4-(4-formyl-2-methoxyphenoxy)-2-(trifluoromethyl)benzonitrile; [Show Image] To a solution (15 mL) of 4-hydroxy-3-methoxybenzaldehyde (1.00 g) in dimethyl sulfoxide were added lithium carbonate (721 mg) and 4-fluoro-2-(trifluoromethyl)benzonitrile (1.49 g), and the mixture was stirred at 100C for 2 days. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and filtered, and the filtrate was concentrated under reduced pressure. The residue was recrystallized from ethyl acetate/n-heptane to give the title compound as a colorless solid (yield: 1.91 g, 92%). 1H-NMR (DMSO-d6, 300 MHz):delta3.84 (3H, s), 7.26 (1H, dd, J = 8.7, 2.5 Hz), 7.48 (1H, d, J = 7.9 Hz), 7.57 (1H, d, J = 2.5 Hz), 7.67 (1H, dd, J = 7.9, 1.7 Hz), 7.72 (1H, d, J = 1.7 Hz), 8.12 (1H, d, J = 8.7 Hz), 10.02 (1H, s).
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Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2450352; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts