Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 2-(Cyanomethyl)benzonitrile
To a solution of 2-cyanophenylacetonitrile 26 (300mg, 2.11mmol) and 1, 3, 5-triazine (205.3mg, 2.53mmol) in MeOH (10.6mL) was added 28% NaOMe methanol solution (2.04g, 10.6mmol). The mixture was stirred at ambient temperature for 1h. The reaction mixture was poured into with 10% NH4Cl solution and MeOH. After removing the solvent, EtOAc and H2O was added. After separating EtOAc, the aqueous phase was extracted with EtOAc twice. The combined organics were dried over MgSO4, filtered, and concentrated in vacuo. The crude product was stirred in iPrOH/Heptane. The solid was collected after filtration to give the known amino-isoquinoline 27 (319.1mg, 81.6%) as pale yellow solid. The product was identified with previously reported data.
The synthetic route of 3759-28-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hayashida, Joji; Yoshida, Shinya; Tetrahedron Letters; vol. 59; 43; (2018); p. 3876 – 3879;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts