Continuously updated synthesis method about 115279-73-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Aminophenyl)cyclopentanecarbonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 115279-73-7, The chemical industry reduces the impact on the environment during synthesis 115279-73-7, name is 1-(4-Aminophenyl)cyclopentanecarbonitrile, I believe this compound will play a more active role in future production and life.

In a 500 ml four-necked flask equipped with a stirrer, thermometer and distillation system, add 100 g of N,N-dimethylformamide, 11.2 g (0.06 mol) of 1-(4-aminophenyl)cyclopentylcarbonitrile (V), 0.2 g of cuprous chloride. While maintaining the internal temperature between 95 and 100 C, 12.2 g (0.05 mol) of methyl 2-[(pyridin-4-ylmethyl)amino]-3-pyridinecarboxylate (IV1) prepared in Example 3 and 30 g N,N-dimethylformamide were added dropwise. The solution of N,N-dimethylformamide is added dropwise in about 1 hour, after which the reaction is stirred at 100-105 C for 4 hours, and the formed methanol is distilled off, the reaction is completed, the temperature is lowered to 20-25 C, and the filter cake is used for filtration. After washing with 20 g of N,N-dimethylformamide, the filtrate was combined, and N,N-dimethylformamide was evaporated under reduced pressure. The residue was crystallized from methyl t-butyl ether, filtered and dried. 18.3 g of a white solid powder of agingatin (I) was obtained in a yield of 92.2%, a liquid phase purity of 99.96% and a melting point of 158.5-160.0 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Aminophenyl)cyclopentanecarbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Cui Qingrong; Liu Yuesheng; Qu Hu; Lv Qiangsan; Ju Lizhu; (10 pag.)CN109020881; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts