Synthetic Route of 628-20-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 628-20-6, name is 4-Chlorobutyronitrile, This compound has unique chemical properties. The synthetic route is as follows.
At 20 C, 31 g (0.5 mol) of ethylene glycol and 2.4 g (0.06 mol) of 60%(w%) sodium hydride. Then, the temperature was raised to 80 C, and 5.2 g (0.05 mol) of 4-chlorobutyronitrile was rapidly added dropwise. After the addition was completed, the reaction was continued for 30 min. After the reaction mixture was cooled to room temperature, the mixture was extracted twice with dichloromethane. The extract was dried over anhydrous sodium sulfate and evaporated to dryness to give 3.36 g of a pale yellow transparent liquid.Cyclopropionitrile was confirmed by NMR analysis. The yield was 97.2% and the purity was 97%.
The chemical industry reduces the impact on the environment during synthesis 4-Chlorobutyronitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Xi’an Modern Chemical Institute; Li Bingbo; Ning Binke; Zhang Xiaoguang; Chen Tao; Wang Wei; Yang Cuifeng; Qian Yishi; (5 pag.)CN106242997; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts