Electric Literature of 1080-74-6, A common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, molecular formula is C12H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the N2 environment, compound 3 (0.065 mmol) and 4 (0.390 mmol) were dissolved in 6 mL of chloroform solution.Three drops of pyridine solution were added dropwise, and the mixture was reacted at 75 C for 16 hours. The solvent was evaporated under reduced pressure and purified by residue column chromatography to yield white product NITI-1 (yield 86%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chinese Academy Of Sciences Chemical Institute; Zhu Xiaozhang; Xu Shengjie; Zhou Zichun; (23 pag.)CN109485635; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts