Electric Literature of 179898-34-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 179898-34-1 as follows.
Example 54 3 ‘-({ [(1 ,1-Dimethylethyl)(dimethyl)silyl] oxy} methyl)-5-fluoro- 3- biphenylcarbonitrile3-bromo-5-fluorobenzonitrile (5.00 g, 25.0 mmol), Pd(OAc)2 (0.15 g), PPh3 (0.60 g) and K2CO3 (5.18 g, 37.5 mmol) were dissolved in dioxane (60 mL). The mixture was heated at 700C for 30 min, then [3 -({[(l,l-dimethylethyl)(dimethyl)silyl] oxy} methyl) phenyljboronic acid (7.99 g, 30.0 mmol) was added. The mixture reaction was stirred at reflux overnight. The solvent was removed under reduced pressure, then diluted with CH2Cl2 (100 mL). The organic layer was washed with water (50 mL) and brine (50 mL). And the organic layer was dried over Na2SOzI. The product 3’-({[(l,l-dimethylethyl) (dimethyl)silyl]oxy} methyl)-5-fluoro-3-biphenylcarbonitrile (5.10 g, 60%) was purified by flash column chomatography. 1H NMR (400 MHz, CDCl3) delta 7.67 (t, J=5.2 Hz, 1 H), 7.54-7.32 (m, 5 H), 4.81 (s, 2 H), 0.94 (s, 9 H), 0.13 (s, 6 H).
According to the analysis of related databases, 179898-34-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/100169; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts