Related Products of 114344-60-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114344-60-4 as follows.
3-Bromo-2-(1-((1s,3s)-3-methylcyclobutyl)-5-oxo-2,5-dihydro-1H-pyrrol-3-ylamino)benzonitrile4-Methoxy-1-((1s,3s)-3-methylcyclobutyl)-1H-pyrrol-2(5H)-one (4.20 g, 22.02 mmol) and 2-amino-3-bromobenzonitrile (5.94 g, 30.16 mmol) in acetic acid (15 mL) were warmed to 80 C. to give an amber solution. Methanesulfonic acid (3.57 mL, 55.04 mmol) in acetic acid (4 mL) was added drop wise into the reaction at 80 C. over one hour. After the addition, the reaction was stirred for another 30 minutes at 80 C. to complete. All of acetic acid was removed under high vacuum at 50 C. The residual was diluted in methylene chloride (150 mL) and then titrated into a half-saturated NaHCO3 aqueous solution at 0 C. slowly. The organic layer was dried through MgSO4, filtrated and evaporated to dry. The crude material was added to a silica gel column and was eluted with 0-10% methanol in methylene chloride to give an orange-yellow solid as the title compound (5.27 g, 68%) 1H NMR(300 MHz, CHLOROFORM-d) delta ppm 7.88 (dd, J=8.1, 1.4 Hz, 1 H) 7.67 (dd, J=7.7, 1.4 Hz, 1 H) 7.23 (t, J=8.01 Hz, 1 H) 6.02 (s, 1 H) 4.85 (s, 1 H) 4.39-4.63 (m, 1 H) 4.11 (s, 2 H) 2.29-2.50 (m, 2 H) 1.90-2.20 (m, 1 H) 1.59-1.79 (m, 2 H) 1.09 (d, J=6.5 Hz, 3 H). MS APCI, m/z=346.1/348.1 HPLC 2.19 min.
According to the analysis of related databases, 114344-60-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; US2008/318943; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts