Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H3FN2O2
EXAMPLE 66(R)-trans-1-carbamoyl-4-adamantyl 3-(5-cyano-2-oxo-2,3-dihydro-1 H- benzo[d]imidazol-1 -yl)pyrrolidine-1 -carboxylateStep 1; A mixture of (R)-1-(methoxycarbonyl)adamantan-4-yl 3-aminopyrrolidine-1- carboxylate HCI salt (166 mg, 0.46 mmol), prepared as described in WO 2009/131669, 4-fluoro-3-nitrobenzonitrile (1 15 mg, 0.69 mmol), i-Pr2NEt (0.25 ml_, 1.4 mmol) and n-PrOH (3 ml.) was heated at 120 0C for 1 h in the microwave. The mixture was diluted with EtOAc (100 ml_), washed with water (10 ml_), 2percent aq HCI (10 ml.) and brine (10 ml_), and dried over Na2SO4. Removal of the solvent left an orange oil (293 mg) which was purified by prep HPLC to afford (R)-1- (methoxycarbonyl)adamantan-4-yl 3-((4-cyano-2-nitrophenyl)amino)pyrrolidine-1- carboxylate (80 mg, 37percent) as a yellow oil. LC-MS Method 1 tR = 1.93 min, m/z = 469.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; LEFTHERIS, Katerina; SINGH, Suresh, B.; TICE, Colin, M.; YE, Yuanjie; ZHUANG, Linghang; WO2010/141424; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts