In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67515-59-7 as follows. category: nitriles-buliding-blocks
To a solution of 4-fluoro-3-(trifluoromethyl)benzonitrile (10 g), /-PrOH (8.15 mL) in tetrahydrofuran (THF) (90 mL) stirred under nitrogen at -10 C was added solid NaH (3.46 g) portionwise during 30 min. The reaction mixture was stirred at -10 C for 6 h. The reaction mixture was quenched with water, partitioned between ether (.100 mL) and water (50 mL).The organic phase was dried over magnesium sulphate and evaporated in vacuo to give the crude product 4-[(1-methylethyl)oxy]-3- (trifluoromethyl)benzonitrile (D10) (15 g).
According to the analysis of related databases, 67515-59-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; DENG, Guanghui; LIN, Xichen; REN, Feng; ZHAO, Baowei; WO2011/134280; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts