Reference of 6574-99-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6574-99-8, name is 3,4-Dichlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General Procedure C. The nitrile (10 mmol) was added in several portions, over 0.5 h to a solution of the nBuMgCl (12 mmol) in toluene (20 mL). The reactions were monitored by TLC and heated where necessary. Generally, after 2 h stirring at room temperature, the reaction was complete. The reaction mixture was poured onto ice and concentrated H2S04 (2 mL) was added. Hydrolysis of the intermediate imine usually occurred at room temperature after several minutes, however, for some substrates, heating was necessary to effect this transformation. The organics were extracted into Et20, dried (MgS04), filtered, and reduced to an oil in vacuo. Example 58 1-(3, 4-Dichloro-phenyl)-pentan-l-one. Following General Procedure C, this compound was prepared in 93% yield and employed in the next step of the reaction as the crude material.
The synthetic route of 3,4-Dichlorobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; ORGANIX, INC.; WO2005/34878; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts