2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 2042-37-7
Intermediate Example Int3.1(6-Bromo-[1 ,2,4]triazolo[1 ,5-a]pyridin-2-yl)-o-cyanophenyl-amineTo a stirred solution of 213 mg (1 mmol) Int1.2 in THF (2.5 mL) was added 364 mg (2 mmol, 2 eq) 2-Brombenzonitril, 183 mg (0.2 mmol, 0.2 eq) Pd2(dba)3, 374 mg (0.6 mmol, 0.6 eq) rac-BINAP and 240 mg (2.5 mmol, 2.5 eq) NaOtBu at room temperature in a microwave reactor. The solution was heated at 150 C for 50 min under microwave irradiation. After cooling, the solution was filtered and evaporated. Subsequent purification by by preparative reverse phase HPLC gave 186 mg (59 %) of the title compound.1H-NMR (300 MHz, d6-DMSO): delta = 9.56 (1H, s), 9.16 (1 H, s), 7.91 (1 H, d), 7.72 (1 H, d), 7.70 (1 H, d), 7.62 (1H, dd) 7.54 (1 H, d), 7.15 (1H, dd) ppm. UPLC-MS: RT = 1.15 min; m/z (ES+) 315.2 [MH+]; required MW = 314.2.
The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; KOPPITZ, Marcus; KOSEMUND, Dirk; SCHIROK, Hartmut; BADER, Benjamin; LIENAU, Philip; WENGNER, Antje; BRIEM, Hans; HOLTON, Simon; SIEMEISTER, Gerhard; PRECHTL, Stefan; BOeMER, Ulf; WO2011/63908; (2011); A1;,
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