Related Products of 77-57-6,Some common heterocyclic compound, 77-57-6, name is 1-Phenylcyclopentanecarbonitrile, molecular formula is C12H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1 -phenyl- l-cyclopentanecarbonitrile (1.500 mL, 8.76 mmol, Acros Organics USA) in MeOH (40 mL) was added a solution of palladium, 10wt. % on activated carbon (93 mg, 0.876 mmol, Aldrich) in EtOAc (0.5 mL) and concentrated HCl (0.4 mL). The reaction mixture was stirred at room temperature under H2 (42 psi) overnight. The reaction mixture was filtered through celite, washed the filter-cake with MeOH. The combined filtrates were concentrated and H2O was added to the residue. The aqueous solution was extracted with EtOAc. The aqueous layer was basified (pH >10) using saturated aqueous NaHCtheta3 and extracted with EtOAc. The combined organic extracts were dried over MgSO4, concentrated, and dried in vacuum to give (l-phenylcyclopentyl)methanamine as light yellow oil, which was used in the next step without purification.
The synthetic route of 77-57-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2009/137404; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts