Synthetic Route of 261762-98-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 261762-98-5, name is 3-Chloro-2-fluorophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.
1-Bromomethyl-3-chloro-2-fluoro-benzene (10.00 g, 44.80 mmol) and KCN (5.80 g, 89.07 mmol) were mixed in DMF and the resulting reaction mixture was stirred at 75 C. for 2 days. The reaction mixture was cooled to room temperature, and water was added. The mixture was extracted with Et2O (3¡Á300 mL). The combined organic phases were washed with H2O (2¡Á200 mL) and brine (1¡Á200 mL), then dried over MgSO4 and concentrated. The crude nitrile was taken up in water and KOH (5.00 g, 89.11 mmol) was added. The resulting mixture was refluxed for 14 hours. After cooling to room temperature, the reaction mixture was diluted with water and washed with Et2O (2¡Á150 mL). The aqueous layer was acidified with concentrated HCl and was extracted with Et2O (3¡Á300 mL). The combined organic phases were washed with H2O (2¡Á200 mL) and brine (1¡Á200 mL), then dried over MgSO4 and concentrated to afford the title acid.
The chemical industry reduces the impact on the environment during synthesis 3-Chloro-2-fluorophenylacetonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Allerghan, Inc.; US2008/194650; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts