In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 646-20-8 as follows. SDS of cas: 646-20-8
Step 1: Preparation of 2-Aminocyclohex- 1-en ecarbonitrile (I-7a) To cold toluene (20 mL) was added 60% NaH (720 mg, 18.0 mmol) slowly andfollowed by a solution of 1,5-dicyanopentane (2.1 mL, 16.37 mmol) in toluene (5 mL)slowly at 0C. The resulting mixture was refluxed for 4 h and cooled to roomtemperature. The reaction mixture was quenched with ethanol (2 mL), water (20 mL) 15 and acetic acid (2 mL). The organic layer was separated and aqueous layer wasextracted with ethyl acetate (3 x 20 mL). The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. Water was added to the crude residue, then filtered and washed with hexane to afford 850 mg (42%) of 2-aminocyclohex-1-enecarbonitrile () as a pale brown solid.20 1H NMR (400 MHz, CDCI3): 64.21 (5, 2H), 2.2-2.12 (m, 4H), 1.75-1.55 (m, 4H).
According to the analysis of related databases, 646-20-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; JIRICEK, Jan; KONDREDDI, Ravinder Reddy; SMITH, Paul William; WO2014/37900; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts