Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 499983-13-0, name is 4-Bromo-3-fluorophenylacetonitrile, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-3-fluorophenylacetonitrile
A solution of 2-(4-bromo-3-fluorophenyl)acetonitrile (0.78 g, 3.64 mmol) in H2SO4 (5 mL) and H20 (5 mL) was stirred at 100 C for 16 h. After LCMS analysis showed the starting material had disappeared, the mixture was dissolved in H20 (20 mL) and extracted by EA (20 mL). The organic layer was dried over Na2S04, filtered and concentrated to yield a white solid of 2-(4- bromo-3-fluorophenyl)acetic acid (0.7 g, 2.046 mmol, 56.1% yield): l NMR (400 MHz, CD3OD) 5 7.53 (t, J= 7.8 Hz, 1H), 7.16 (dd, J =9.8, 1.9 Hz, 1H), 7.02 (d, J= 8.0 Hz, 1H), 3.61 (s, 2H).
The synthetic route of 499983-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; EIDAM, Hilary Schenck; DEMARTINO, Michael P.; GONG, Zhen; GUAN, Amy Huiping; RAHA, Kaushik; WU, Chengde; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; CHEUNG, Mui; WO2014/141187; (2014); A1;,
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