Synthetic Route of 57381-34-7, The chemical industry reduces the impact on the environment during synthesis 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.
Preparation 10: 1-[5-Chloro-2-(4-methyl-piperazin-1-yl)-phenyl]-ethanone; STEP A; A mixture of 5-chloro-2-fluoro-benzonitrile (500 mg, 3.21 mmoi), K2CO3 (1.32 g, 9.64 mmol) and 1-methyi-piperazine (482 mg, 4.81 mmoi) in DMSO (6.4 ml) was stirred at 100C for 6 h and then partitioned between water and Et2O. The organic phase was dried over Na2SO4 and evaporated in vacuo. The crude mixture was purified by column chromatography (eluent: DCM/MeOH/NH4OH 98:2:0.1) to give 660 mg of 5-chloro-2-(4-methyl-piperazin-1-yl)-benzonitrile. Y= 87%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DAC S.R.L.; WO2007/113249; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts