154532-34-0, name is 3-(tert-Butyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 154532-34-0
A mixture of 0.84 g (5.1 mmol) 3-tert-butyl-benzonitrile, 1 mL (25% aq. NH3) and 0.1 g Raney-Nickel is hydrogenated at 40 C. After completion of reaction, the catalyst is filtered off and washed with MeOH. The solvent is removed in vacuo and the residue is purified by chromatography on silica gel (DCM/MeOH 90/10) to give 0.84 g of the desired product as a green oil.tR (HPLC, Nucleosil C18 column, 20-100% CH3CN/H2O/6 min, 100% CH3CN/1.5 min, 100-20% CH3CN/H2O/0.5 min, flow: 1.0 ml/min): 2.81 min.Rf: (hexane/AcOEt=95/5): 0.26MS (ES+): 164=[M+H]+ 1H-NMR (400 MHz, CDCl3): 7.40-7.33 (m, 3H), 7.20-7.18 (m, 1H), 3.90 (s, 2H), 1.60 (bs, 2H), 1.39 (s, 9H).
The synthetic route of 154532-34-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Betschart, Claudia; Lerchner, Andreas; Machauer, Rainer; Rueger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob; US2008/132477; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts