Simple exploration of 658-99-1

The chemical industry reduces the impact on the environment during synthesis 2-(3,4-Difluorophenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Electric Literature of 658-99-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 658-99-1, name is 2-(3,4-Difluorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Step A: Preparation of 2-(3,4-Difluorophenyl)-2- methylpropanenitrile; [0718] 2-(3,4-Difluorophenyl)acetonitrile (25.0 g, 163 mmol) and MeI(25.4 mL, 408 mmol) were dissolved in DMF (163 mL) and added dropwise to a suspension of sodium tert-butoxide (39.2 g, 408 mmol) in DMF at 0C. The resulting reaction mixture was stirred at 00C for 1 hour and then allowed to warm to ambient temperature for 1 hour. The reaction mixture was diluted with 400 mL of EtOAc, added to a separatory funnel, partitioned with water, washed 3 times with 200 mL of water, separated, dried over Na2SO4, and concentrated in vacuo to give the title compound (26.45 g) as a yellow oil.

The chemical industry reduces the impact on the environment during synthesis 2-(3,4-Difluorophenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts