Reference of 6575-11-7,Some common heterocyclic compound, 6575-11-7, name is 2-Amino-6-chlorobenzonitrile, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2-amino-6-chlorobenzonitrile (17.72 g, 0.116 mol) and tetrahydro-2,5-dimethoxyfuran (0.116 mol) in HOAc (100 ml) was stirred and refluxed for 30 mm. Subsequently, the mixture was cooled and evaporated. The residue was purified over silica gel on a glass filter (eluent:DCM). The product fractions were collected and the solvent was evaporated. The residue was crystallized from EtOH. Yield: 18.83 g of intermediate 3 (80% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-6-chlorobenzonitrile, its application will become more common.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; Meerpoel, Lieven; Maes, Louis Jules Roger Marie; de Wit, Kelly; Augustyns, Koen Jan Ludovicus; US2014/45827; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts