Adding a certain compound to certain chemical reactions, such as: 159847-81-1, name is Methyl 2-amino-5-cyanobenzoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 159847-81-1, Product Details of 159847-81-1
b. 5-Cyano-2-[2-(3-methyl-isoxazol-5-yl)-acetylamino]-benzoic acid methyl ester A solution of 2-amino-5-cyano-benzoic acid methyl ester (1. 50G, 8.51 mmol) and (3-methyl-isoxazol-5-yl) -acetic acid (1.32 g, 9.36 mmol) in 40 ml of POCl3 was heated at 80 C for 2 hr and then cooled to RT. Treated with 50 mL of EtOAc, the mixture was washed with H20 (3 x 40 ml), sat. NAHC03 (40 ml), brine (40 ml) and dried (NA2S04). Removal of the solvent under reduced pressure gave 2.31 g (91 %) of product as a light yellow solid : H-NMR (CDC13 ; 400 MHz) 8 11.49 (s, 1H), 8.85 (d, 1H, J = 8.8 Hz), 8.35 (d, 1H, J = 2. 0 Hz), 7.79 (dd, 1H, J = 8. 8,2. 0 Hz), 6.20 (s, 1H), 3.97 (s, 3H), 3.95 (s, 2H), 2.33 (s, 3H). Mass spectrum (ESI, m/z) : Calcd. for CLSHL3N3O4 300.1 (M+H), found 299.9.
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Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2005/9967; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts