Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64248-64-2, name is 2,5-Difluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 64248-64-2
EXAMPLE 23 (7RS,9aSR)-7-(4-Fluorophenoxy)methyl-2-(2-cyano-4-fluorophenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine STR38 A mixture of 1.05 g (6.17 mmol) of (7RS,9aSR)-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (U.S. Pat. No. 5,326,874) and 1.29 g (9.25 mmol) of 2,5-difluorobenzonitrile in 20 mL of DMSO was heated at 100 C. for 16 h. The mixture was cooled to room temperature, acidified with 1M HCl, washed with ether (3*), made basic with conc. ammonium hydroxide, and extracted with ethyl acetate (3*). The combined organic layers were washed with water (3*), dried (magnesium sulfate), filtered and evaporated. Purification by silica gel MPLC with 90:10 chloroform:methanol gave 0.51 g of (7RS,9aSR)-7-hydroxymethyl-2-(2-cyano-4-fluorophenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine.
According to the analysis of related databases, 64248-64-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Pfizer Inc.; US5852031; (1998); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts