Related Products of 26830-95-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26830-95-5 as follows.
Step 1. Preparation of 2-amino-4-methyl-benzonitrile (B10-1): A solution of 4-methyl-2-nitrobenzonitrile (10 g, 61.72 mmol) in ethanol (200 mL) was charged to a Parr reactor and treated with 10% Pd/C (1 g). The contents of the reactor were then hydrogenated at 50 Psi hydrogen pressure 25 C. for 90 minutes. The reaction mixture was filtered through a Celite bed and washed with ethanol. The combined filtrates were the concentrated to provide B10-1. Yield: 8.5 g. 1H NMR (CDCl3): delta 7.28 (s, 1H), 6.5-6.62 (m, 2H), 4.2-4.42 (broad, 2H) and 2.3 (s, 3H). Mass: (M-1) 132 calculated for C8H8N2. The product was used without further purification to prepare B10-2 in the step described below.
According to the analysis of related databases, 26830-95-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Pfizer Inc.; US2009/54395; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts