Adding a certain compound to certain chemical reactions, such as: 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1009-35-4, COA of Formula: C7H3FN2O2
N-(4-Cvano-2-nitrophenyl)-N-methylglycineA mixture of 4-fluoro-3-nitrobenzonitrile (3.0 g) and sarcosine (2.53 g) with sodium hydrogen carbonate (2.39 g) in water (15 mL) and ethanol (15 mL) was heated at 8O0C. After 2 hours, the reaction was concentrated to half its volume and poured into IM HCl (50 mL). The aqueous solution was extracted with ethyl acetate and then with chloroform. The combined organic phases were dried over sodium sulfate and concentrated under reduced pressure. The residue was suspended in a minimum of dichloromethane and filtered yielding 3.74 g of product.MS TES): 236 (MH+) for Ci0H9N3O41H NMR (DMSO-D^ delta: 2.87 (s, 3H); 4.19 (s, 2H); 7.13 (d, IH); 7.82 (dd, IH); 8.29 (d,IH); 13.03 (s,lH).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-3-nitrobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/71981; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts