Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, A new synthetic method of this compound is introduced below., name: 3-Amino-4-chlorobenzonitrile
Step A:2-Th ioxo-2 , 3-d ihyd robenzoth iazole-5-carbon itrile; A mixture of 3-amino-4-chlorobenzonitrile (200 mg, 1.32 mmol) and potassium o-ethyl- xanthate (422 mg, 2.64 mmol) in lambda/-methyl-2-pyrrolidone (1.5 ml.) was heated at 140 0C for 2 h. After cooling, the mixture was poured into ice-water. Then concentrated hydrochloric acid(0.2 ml.) was added. The solid was collected, washed with water and dried to give 2-thioxo-2,3-dihydrobenzothiazole-5-carbonitrile 250 mg (99 %).1H NMR (400 MHz, CDCI3): delta 7.53-7.50 (m, 2 H); 7.49 (s, 1 H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts