Synthetic Route of 4640-66-8, A common heterocyclic compound, 4640-66-8, name is 4-Chlorophenacylcyanide, molecular formula is C9H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-carbonyl-3-(4-chlorophenyl)propanenitrile (I-c) (180 mg)And thiourea (II) (152 mg) were added to methanol (5 mL) at room temperature.Add to reactionPeroxy tert-butyl alcohol (288 muL)And azobisisobutyronitrile (33mg),Stir at room temperature for 2 hours. After the reaction was completed, saturated aqueous sodium bicarbonate (50 mL) was added.After extraction with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a crude product.The crude product was isolated and purified by column chromatography (ethyl acetate: petroleum ether (v/v) = 3:7).Yielded 191 mg of 2-amino-4-(4-chlorophenyl)-5-carbonitrilethiazole (III-c) as a white solid,Yield: 81%.
The synthetic route of 4640-66-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianjin University; Du Yunfei; Sun Jiyun; Zhao Kang; (8 pag.)CN107739350; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts