Adding a certain compound to certain chemical reactions, such as: 103146-25-4, name is 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103146-25-4, category: nitriles-buliding-blocks
Example 3 Preparation of citalopram To 20g citalopram diol intermediate alkali crystal obtained in Example1, 200ml toluene and 80g phosphoric acid were added, the solution was stirred at 80C for 2.5 hours and then cooled down to 50C with ice bath, its PH was adjusted to 10 with 20% NaOH solution. Then toluene solution was separated, washed with water and dried, disposed with silica gel and filtrated, evaporated to eliminate toluene to give 17.5g citalopram oil substance. The purity of the product was 99.65% (HPLC, area normalization method), and the yield was over 86%.
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Reference:
Patent; Hangzhou Minsheng Pharm. Co., Ltd.; EP1700851; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts