922728-21-0, The chemical industry reduces the impact on the environment during synthesis 922728-21-0, name is 4,4-Difluorocyclohexanecarbonitrile, I believe this compound will play a more active role in future production and life.
[(4,4-Difluorocyclohexyl)methyI]amineLiAlH4 (2.20 g, 57.9 mmol) was added to a solution of 4,4- difluorocyclohexanecarbonitrile (6.10 g, 42.0 mmol) in THF (250 mL) at ambient temperature. The reaction mixture was refluxed to 75C and stirred for four hours. The reaction mixture was cooled to 00C and slowly quench by addition of MeOH over 1 hour. The mixture was filtered over a Celite pad and the filtrate was concentrated. The product was purified by distillation (65C/15 mmHg) to afford the title compound as a colorless liquid. Yield: 2.55 g (40%). 1H NMR (400 MHz, CHLOROFORM-D): delta 1.17 – 1.46 (m, 3 H), 1.52 – 1.94 (m, 2 H), 2.03 – 2.32 (m, 2 H), 2.57 – 2.70 (m, 2 H).
The chemical industry reduces the impact on the environment during synthesis 4,4-Difluorocyclohexanecarbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; WO2007/13848; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts