16588-02-6, The chemical industry reduces the impact on the environment during synthesis 16588-02-6, name is 2-Chloro-5-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
In order to prepare a reaction mixture, a diselenide compound represented by a general formula R?-CH2—-a solvent, and a reducing agent were prepared. As the diselenide compound represented by the general formula R??-CH2-Se-Se–CH2—R? of the reaction mixture, various substances such as (SeCH2COOEt)2? (p-NO2PhCH2Se)2, (p-CNPhCH2Se)2, and the like were used. The diselenide compounds were as shown in [Table 1]. About 0.6 eq. of the diselenide compound was used. As the solvent, anhydrous dimethylformaldehyde (DMF) was used. Further, as the reducing agent, about 0.6 eq. of dithiothreitol (DTT) was used.10291] To be specific, the reaction mixture was prepared by adding the diselenide compound represented by the general formula R?CH2Se-Se-CH2—-R? and the reducing agent to 2 mL of the solvent. The reaction mixture was stirred for 1 hour at a constant temperature of 60 C.10292] After the reaction mixture was prepared, an aromatic compound as a starting material for producing the selenophene-fused aromatic compound was added to the reaction mixture at a time. Then, the reaction mixture was stirred for 30 minutes at a constant temperature of 60 C.10293] As the base to be added afier the starting material is added to the reaction mixture with stirring, a weak base K2C03 was used. 2.5 eq. of the base was added to the reaction mixture at room temperature with stirring for 24 hours at a constant temperature of 60 C.10294] After the base was added and the stirring was finished, it was observed that the starting material was completely consumed by using a thin layer chromatography in a mixture of ethyl acetate:hexane (EA:Hex). The solvent contained in the reaction mixture was removed in a vacuum, and a crude solid was extracted 3 times by using about 25 mE of a solvent including dichloromethane:water (1:1). An organic phase collected through the extraction process was dried in an anhydrous environment by using MgSO4, and the solvent was evaporated in a vacuum. The residue was refined by column chromatography using a silica gel column. A pure product, i.e. the selenophene-fused aromatic compound produced in the present Example, was eluted by using ethyl acetate and hexane, and recrystallized by using methanol and then filtered.
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-5-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Samsung Life Public Welfare Foundation; Industry-Academia Cooperation Group of Sejong University; Lim, Dongyeol; Nam, Do-Hyun; Dubey, Rashmi; Lee, Hangeun; US2014/213790; (2014); A1;,
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